Wines have been produced in southern France since pre-Roman times. Presently, the official Côtes du Rhône AOC covers 27 grape varieties, and the region encompasses 200 km, from Vienne in the north to Avignon in the south and from the foothills of the Massif Central in the west to the fore-slopes of the Vaucluse and Luberon mountains in the east. Boasting 17 distinctive crus, including famous names such as Châteauneuf-du-Pape, Gigondas, and Vacqueyras, the Rhône region produces around 3.3 million hectoliters—or 419 million bottles—of wine per year, making it one of the largest single appellation regions in the world.

Drinking wine (in moderation) is known to reduce visible signs of aging. Antioxidants such as flavonoids, resveratrol and tannins encourage collagen production and protect the skin from harmful pollution and UV radiation. Wine can even improve skin radiance and even out skin tone by reducing stress levels and free radical damage.

The wine making process does not fully extract all antioxidants from grapes, and the resulting pomace often creates environmental issues when discarded. Proscien has worked closely with local wineries to devise a mild extraction process which recaptures active compounds and fine wine aromas from pomace for skin care purposes.